Biologie Jobs -
- Zwei Doktorandenstellen in Oekologie (PhD in Ecology) (Bayreuth)
SCIENCE-JOBS-DE Stellenausschreibung (vacancies)
----------------------------------------------------------------------Ecology: Two PhD Positions (Universität Bayreuth)
“Combined effects of climate change, extreme events and habitat fragmentation on insect diversity and biotic interactions in an alpine region”
Rationale
Climate change and habitat loss are two major drivers of species extinctions and are in the current focus of political discussions. Two PhD positions are available in a forthcoming multidisciplinary Bavarian research project on effects of climate change on ecosystems (FORKAST). In this project we will study the combined risks of climate change and habitat fragmentation for species diversity of butterflies and bees, plant-herbivor-antagonist and plant-pollinator interactions in grasslands along an altitudinal gradient in the German Alps. Small-scale field experiments, analyses of temporal species turnover and population genetics of alpine butterflies will complement the research program.
The PhD-students will be located at the University of Bayreuth (Germany), http://www.uni-bayreuth.de/, with field work in the beautiful national park Berchtesgaden http://www.nationalpark-berchtesgaden.bayern.de/.Requirements
Applicants should hold a MSc or Diploma degree in Biology, Agriculture or related disciplines with preferably a strong background in insect ecology. Knowledge in the fields of plant-insect interactions, population genetics, GIS and statistics, preferably in R+ is desirable. Also experiences in ecological field work as well as insect identification skills will be beneficial. Physical fitness is necessary to reach some remote study sites in the mountains. Furthermore conducting the field work will require a drivers license and an own car will be advantageous. Social skills, the ability to work in a team and interest in independent research are of relevance.Salary and conditions
Salary and benefits are according to a public service position in Germany (TVL 13/2). Start date: 1st of February 2009. The positions are for three years each. The doctoral thesis will be done as a series of English manuscripts.
The University of Bayreuth is one of the leading international centres of Global Change research. We also offer a very nice research atmosphere in a growing and ambitious young research team (http://www.bayceer.uni-bayreuth.de/toek1_pop/de/).Applications
Please send your applications per email before 12th Decembre 2008, including a CV, certificates, a short summary of research interests, and the names (with email address) of two referees to the email addresses given below.
Interviews of successful candidates will be held on 19th Decembre 2008.For further information, please contact
Prof. Dr. Ingolf Steffan-Dewenter (Ingolf.Steffan@uni-bayreuth.de), and Dr. Jochen Krauss (Jochen.Krauss@uni-bayreuth.de), Population Ecology Group, Animal Ecology I, University of Bayreuth.----------------------------------------------------------------
Von:
Jochen Krauss
jochen.krauss@uni-bayreuth.de
Populationsökologie, Tierökologie I, Universität Bayreuth
BayreuthAnsprechpartner: ingolf.steffan@uni-bayreuth.de
----------------------------------------------------------------
----------------------------------------------------------------------
Mehr Informationen zu SCIENCE-JOBS-DE finden Sie im WWW unter der
Adresse http://jobs.uni-hd.de, insbesondere zu den Themen An/Abmelden,
Informationen fuer Anbieter und "Netiquette" - more information on
SCIENCE-JOBS-DE is available on the Web at http://jobs.uni-hd.de,
especially regarding subscription and unsubscription, information for
offerings and "netiquette". - Sensitivierung von Melanomzellen für Todesliganden-vermittelte Apoptose (Berlin, Campus Mitte, Charitéplatz 1)
SCIENCE-JOBS-DE Stellenausschreibung (vacancies)
----------------------------------------------------------------------SCIENCE-JOBS-DE Stellenausschreibung (vacancies)
------------------------------------------------------------------------ Stellenbeschreibung: Wissenschaftler/Postdoc, BAT IIa, ab 1.1.2009, für 2,5 Jh. mit Verlängerungsmöglichkeit, gefördert durch die Deutsche Krebshilfe.
-- Campus: Die Charite in Berlin ist eines der größten und forschungsaktivsten medizinischen Zentren in Europa. Der Standort ist mitten in Berlin nahe dem Brandenburger Tor.
-- AG: Unsere wissenschaftliche Arbeitsgruppe "Apoptoseregulation in Hauttumoren" mit derzeit etwa 10 vorwiegend naturwissenschaftlichen Mitarbeitern verbindet Grundlagenforschung mit der medizinischen Anwendung.
-- Literatur: Medline unter "eberle j and berlin"
-- Bewerbungen: Bitte nur per E-mail mit Zeugnissen und kurzem Lebenslauf.
Thema: Sensitivierung von Melanomzellen für Todesliganden-vermittelte Apoptose.
Die Regulation der Apoptose stellt einen wichtigen Schlüssel zum Verständnis von Tumorerkrankungen und zur Entwicklung von therapeutischen Ansätzen dar. Gerade Todesliganden wie TRAIL zeigten in-vitro eine besondere Eignung für Melanomzellen und stellen daher einen wichtige Hoffnungsträger für das derzeit therapieresistente metastasierte maligne Melanom dar. Im vorliegendem Projekt geht es insbesondere um die Entwicklung von Strategien zur weiteren Sensitivierung von Melanomzellen für TRAIL und CD95L sowie zur Überwindung von Resistenzen.-- English abstract:
Sensitization of melanoma cells for death ligand-mediated apoptosis.
Death ligands as TNF-alpha, CD95L/FasL and TRAIL secreted by tumor-infiltrating T-lymphocytes trigger apoptosis in target cells. Furthermore, TRAIL is a promising candidate for tumor therapy due to its selective targeting of tumor cells. However, apoptosis resistance may be developed. Decreasing melanoma cell resistance to death ligands may support an anti-tumor immune response and may facilitate TRAIL-related strategies. As shown in previous work, melanoma cells can be efficiently targeted by death ligands in vitro and in mouse models. As concluded from established models, resistance to CD95 was correlated with loss of receptor and an increased ratio of Bcl-2/Bax, whereas TRAIL resistance correlated with loss of DR4, inactivation of DR5 and downregulation of initiator caspases. In this project, resistance models to death ligands will be refined, and the relations to survival pathways as MAPK, PKB/Akt and NF-kappaB will be investigated. Thus, strategies shall be identified f!
or overcoming death ligand resistance, which will be investigated in suitable mouse models. Finally, relevant markers shall be identified in a retrospective immunohistological study in melanoma biopsies. The value of death ligands for melanoma therapy shall be defined and suitable combinations shall be identified.----------------------------------------------------------------
Von:
PD Dr. Jürgen Eberle
juergen.eberle@charite.de
Charité - Universitätsmedizin Berlin, Klinik für Dermatologie, Venerologie und Allergologie
Berlin, Campus Mitte, Charitéplatz 1Ansprechpartner: juergen.eberle@charite.de
----------------------------------------------------------------
----------------------------------------------------------------------
Mehr Informationen zu SCIENCE-JOBS-DE finden Sie im WWW unter der
Adresse http://jobs.uni-hd.de, insbesondere zu den Themen An/Abmelden,
Informationen fuer Anbieter und "Netiquette" - more information on
SCIENCE-JOBS-DE is available on the Web at http://jobs.uni-hd.de,
especially regarding subscription and unsubscription, information for
offerings and "netiquette".----------------------------------------------------------------------
Mehr Informationen zu SCIENCE-JOBS-DE finden Sie im WWW unter der
Adresse http://jobs.uni-hd.de, insbesondere zu den Themen An/Abmelden,
Informationen fuer Anbieter und "Netiquette" - more information on
SCIENCE-JOBS-DE is available on the Web at http://jobs.uni-hd.de,
especially regarding subscription and unsubscription, information for
offerings and "netiquette".